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Neuroendokrine und neurotrophe Verbindungen zwischen Menopause und Risiko by Heba Hassan, Mona El-Banna

Neuroendokrine und neurotrophe Verbindungen zwischen Menopause und Risiko

by Heba Hassan , Mona El-Banna
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Book cover type: Paperback
  • ISBN13: 9786202189064
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 148
  • Original Price: GBP 59.94
  • Language: German
  • Edition: N/A
  • Item Weight: 209 grams
  • BISAC Subject(s): Life Sciences / Biology

Neurodegenerative Erkrankungen, darunter die Alzheimer- und die Parkinson-Krankheit, sind durch einen fortschreitenden Verlust von Nervenzellen gekennzeichnet, der zu kognitiven und motorischen Beeintr�chtigungen f�hrt. Diese Erkrankungen weisen deutliche geschlechtsspezifische Unterschiede in der Pr�valenz und im Verlauf auf, wobei immer mehr Beweise darauf hinweisen, dass die Menopause ein entscheidender Faktor f�r die Anf�lligkeit von Frauen ist. Der R�ckgang von �strogen, Progesteron und anderen neurotrophen Faktoren w�hrend der Menopause st�rt zahlreiche neuroprotektive Prozesse und tr�gt so zum Ausbruch und Fortschreiten der Krankheit bei.Dieses Buch beleuchtet die wichtigsten pathologischen Mechanismen, die den NDs zugrunde liegen, wie Proteinfehlfaltung, oxidativer Stress, mitochondriale Dysfunktion, Neuroinflammation, Apoptose, genetische Anf�lligkeit und Beeintr�chtigung der Blut-Hirn-Schranke. Es wird die modulierende Rolle der Sexualhormone und des insulin�hnlichen Wachstumsfaktors 1 (IGF-1) durch genomische und nichtgenomische Signalwege hervorgehoben, die das neuronale �berleben und die Hom�ostase des Gehirns regulieren. Insgesamt wird die Menopause als ein entscheidender biologischer �bergang dargestellt, der die Anf�lligkeit f�r neurodegenerative Erkrankungen erh�ht, indem er die miteinander verbundenen neuroendokrinen und neurotrophen Netzwerke unterbricht.

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