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New Trends In Chemotherapy: Facile Synthesis, In silico Studies, and Biological Assessment of Novel Pyrazolo[3,4-b]pyridine

by Ibrahim F. Nassar
Save 31% Save 31%
Current price ₹2,861.00
Original price ₹4,165.00
Original price ₹4,165.00
Original price ₹4,165.00
(-31%)
₹2,861.00
Current price ₹2,861.00

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Book cover type: Paperback
  • ISBN13: 9789999320283
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Eliva Press
  • Publisher Imprint: Eliva Press
  • Publication Date:
  • Pages: 58
  • Original Price: USD 42.5
  • Language: English
  • Edition: N/A
  • Item Weight: 91 grams
  • BISAC Subject(s): Chemistry / General

The contemporary work depicts synthesizing an innovative sequence of polyfunctionalized Pyrazolo[3,4-b]pyridine congeners ES1-ES18 and assessed for antimicrobial, antitumor, telomerase inhibition, and Anti-hepatitis B efficacies applying an array of techniques. Fortunately, most of the compounds demonstrated auspicious bio efficiencies. Additionally, in silico simulation was executed for determining the synthetic Pyrazolo[3,4-b]pyridines anticipated mode of action. Compounds ES4, ES5, and ES6 were picked as the most potent and efficient candidates versus the telomerase enzyme [PDB id: 2B2A]. The consequences exposed that compound ES5 is the extremely credible operative in contradiction of telomerase enzyme as it disclosed the best binding score and interaction pose. These initial outcomes may improve in introducing more research strategies converged on pyrazolo[3,4-b]pyridines, exclusively those with anticipated bioefficacy, ultimate ADMET parameters, and constructive prospects.

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