Nichtinvasive orale Alternative zu medikamentösen Insulintherapien bei Diabetes

Name: Nichtinvasive orale Alternative zu medikamentösen Insulintherapien bei Diabetes
Brand: Verlag Unser Wissen
SKU: 9786209886317
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ISBN13: 9786209886317
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: April 1, 2026
Pages: 52
Original Price: USD 56.0
Language: German
Edition: N/A
Item Weight: 82 grams
BISAC Subject(s): Life Sciences / Biochemistry

About The Book

Nichtinvasive Behandlungsalternativen f�r Erkrankungen von Diabetes bis Hypercholesterin�mie stehen an der Spitze der Forschung. Obwohl viele nichtinvasive Verabreichungswege, darunter orale, bukkale und dermale, untersucht wurden, wurde bisher kein Weg nach den Standards der Food and Drug Administration (FDA) vollst�ndig f�r die Anwendung bei Patienten als Alternative zur derzeitigen nadelabh�ngigen Insulinverabreichung zugelassen. 10 12 Dieses Buch konzentriert sich auf zwei neuartige orale Protein-Arzneimittelabgabesysteme: α-Zr(IV)-Phosphat (α-ZrP)-Protein-zweivalentes Metallion und α-Zr(IV)-Phosphat (α-ZrP)-Protein-kationisiertes Rinderserumalbumin (BSA). Glukoseoxidase (GO) dient in diesem Buch als Modellprotein f�r nichtinvasive Alternativen zur Senkung des Blutzuckerspiegels bei Typ-I- und Typ-II-Diabetikern. Anstelle der Verkapselung von GO, einem oralen Medikament zur Behandlung von Diabetes, k�nnen jedoch auch alternative Proteine als orale Medikamente zur Behandlung von Erkrankungen wie Hypercholesterin�mie verkapsel Dieses Experiment untersucht, welche ionisierte Version von BSA (natives BSA-TEPA (-25), BSA-TEPA (0), BSA-TEPA (-13), BSA-TEPA (+5) oder zweiwertige Metallionen (Mg (II), Ca (II) oder Ba (II)), das in ZrP interkaliert ist, zu einer maximalen GO-Bindung und -Freisetzung im Darmbereich f�hrt.

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