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Osteoimmunologia Nella Malattia Parodontale by Burhan K. B., Basim

Osteoimmunologia Nella Malattia Parodontale

by Basim Burhan K. B. , Arunima P. R. , Divya S
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Book cover type: Paperback
  • ISBN13: 9786200727619
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 120
  • Original Price: GBP 52.98
  • Language: Italian
  • Edition: N/A
  • Item Weight: 173 grams
  • BISAC Subject(s): Dentistry / General

I cambiamenti nella composizione e nella quantit� di microbi all'interno dei biofilm della placca dentale possono determinare uno stato di risposta immunitaria locale proinfiammatoria nei tessuti connettivi della barriera epiteliale e gengivale. Le cellule immunitarie proinfiammatorie infiltrate nel tessuto connettivo infiammato secernono fattori locali che inducono una segnalazione paracrina alle cellule ossee adiacenti. L'infiammazione cronica sostenuta interrompe le azioni "accoppiate" osteoclasti-osteoblasti, che in ultima analisi si traducono nella distruzione dell'osso alveolare.Il campo dell'osteoimmunologia � emerso in risposta alla serie di evidenze che dimostrano la stretta interrelazione tra il sistema immunitario e il metabolismo osseo... Le conoscenze molecolari nel campo dell'osteoimmunologia possono portare a nuovi approcci per la prevenzione e il trattamento di diverse condizioni infiammatorie. Come dimostrano i benefici clinici conferiti dal trattamento anti-fattore di necrosi tumorale (TNF)-α e anti-interleuchina (IL)-6 nell'AR, le conoscenze osteoimmunologiche sono ora di evidente importanza nelle applicazioni cliniche. La trasposizione di queste conoscenze alla malattia parodontale in futuro potrebbe giovare al trattamento della parodontite.

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