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Osteoporose Na Menopausa by Nádia Pereira Et Al

Osteoporose Na Menopausa

by Nádia Pereira Et Al
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Book cover type: Paperback
  • ISBN13: 9786209381935
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Novas Edicoes Academicas
  • Publisher Imprint: Novas Edicoes Academicas
  • Publication Date:
  • Pages: 64
  • Original Price: GBP 38.19
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 100 grams
  • BISAC Subject(s): Pharmacology

A osteoporose � uma doen�a metab�lica �ssea silenciosa, geralmente identificada apenas ap�s a primeira fratura, assumindo crescente relev�ncia devido ao envelhecimento populacional, sobretudo feminino. A forma p�s-menop�usica resulta do d�fice de estrog�nios decorrente da fal�ncia ovariana, comprometendo o remodelamento �sseo atrav�s da a��o nos recetores presentes em osteoblastos, osteoclastos e c�lulas imunit�rias. Evid�ncias recentes sugerem ainda que os estrog�nios preservam a homeostase da microbiota e a integridade da barreira intestinal, prevenindo inflama��o e citocinas pr�-reabsortivas. Apesar de n�o fatal, a doen�a reduz significativamente a qualidade de vida e implica custos elevados. As op��es terap�uticas incluem f�rmacos anab�licos, como teriparatida e romosozumab, e agentes antirreabsortivos, como bifosfonatos, denosumab, moduladores seletivos dos recetores de estrog�nios, calcitonina e terap�utica hormonal. Perspetiva-se o desenvolvimento de estrat�gias inovadoras, incluindo engenharia de tecidos e novos alvos moleculares.

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