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Osteoporosi in Menopausa by Nádia Pereira Et Al

Osteoporosi in Menopausa

by Nádia Pereira Et Al
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Book cover type: Paperback
  • ISBN13: 9786209397905
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 68
  • Original Price: GBP 38.19
  • Language: Italian
  • Edition: N/A
  • Item Weight: 105 grams
  • BISAC Subject(s): Pharmacology

L'osteoporosi � una malattia metabolica silenziosa dell'osso, solitamente identificata solo dopo la prima frattura, e sta diventando sempre pi� importante a causa dell'invecchiamento della popolazione, soprattutto femminile. La forma post-menopausale � il risultato della carenza di estrogeni dovuta all'insufficienza ovarica, che compromette il rimodellamento osseo attraverso l'azione sui recettori presenti negli osteoblasti, negli osteoclasti e nelle cellule immunitarie. Recenti evidenze suggeriscono inoltre che gli estrogeni preservano l'omeostasi del microbiota e l'integrit� della barriera intestinale, prevenendo l'infiammazione e le citochine pro-riassorbitive. Sebbene non sia fatale, la malattia riduce significativamente la qualit� della vita e comporta costi elevati. Le opzioni terapeutiche comprendono farmaci anabolizzanti, come teriparatide e romosozumab, e agenti antiriassorbitivi, come bifosfonati, denosumab, modulatori selettivi del recettore estrogenico, calcitonina e terapia ormonale. Si prevede lo sviluppo di strategie innovative, tra cui l'ingegneria tissutale e nuovi bersagli molecolari.

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