P. multocida en Inde - Isolation, résistance et dynamique de la co-infection
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Pasteurella multocida est un pathog�ne important qui provoque le chol�ra aviaire chez les volailles et des infections chez de multiples h�tes. Cette �tude transversale a �valu� sa pr�valence, ses g�notypes, sa r�sistance aux antibiotiques et sa pathog�nicit� chez les volailles commerciales dans neuf �tats indiens. Au total, 191 �chantillons d'os provenant de cas suspects ont �t� cultiv�s et confirm�s par des tests biochimiques et la PCR. Quarante-huit isolats ont �t� identifi�s et g�notyp�s. Les tests de sensibilit� aux antibiotiques (m�thode Kirby-Bauer) ont montr� une sensibilit� de 100 % � l'enrofloxacine, au cotrimoxazole et au chloramph�nicol, tandis que l'ampicilline, l'amoxycilline et la gentamicine pr�sentaient une sensibilit� de 87,5 %. Les tests de pathog�nicit� effectu�s sur des poulets SPFont reproduit les l�sions typiques du chol�ra aviaire, et l'organisme a �t� r�isol� � partir d'oiseaux infect�s. Le g�notypage a r�v�l� des LPS de g�notype 1 (34), de g�notype 3 (6), de g�notype 4 (1) et de g�notype 5 (7). L'�tude a �galement d�tect� des co-infections par ALV, MG et CAV � l'aide de la PCR. Les co-infections ont augment� la gravit� de la maladie, la d�tresse respiratoire, l'immunosuppression et la mortalit�. Les r�sultats mettent en �vidence l'�mergence d'une multir�sistance aux m�dicaments et soulignent l'importance de la bios�curit�, de la vaccination et du diagnostic pr�coce pour un contr�le efficace dans les syst�mes avicoles indiens.
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