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Padronização da Nothapodytes foetida by Ajay Sharma

Padronização da Nothapodytes foetida

by Ajay Sharma , Archana G. Mhase , Arun M. Gurav
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Book cover type: Paperback
  • ISBN13: 9786139430529
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edicoes Nosso Conhecimento
  • Publisher Imprint: Edicoes Nosso Conhecimento
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 34.71
  • Language: Portuguese
  • Edition: N/A
  • Item Weight: 109 grams
  • BISAC Subject(s): Pharmacology

Nas �ltimas d�cadas, houve um crescimento exponencial no campo da fitoterapia devido � sua origem natural, efeitos colaterais m�nimos e considera��o de seguran�a. A comercializa��o da fabrica��o de medicamentos fitoter�picos para atender a essa crescente demanda resultou no decl�nio da sua qualidade, principalmente devido � falta de regulamenta��es adequadas relativas a esse setor da medicina. A necessidade atual � desenvolver uma abordagem sistem�tica e metodologias bem concebidas para a padroniza��o de medicamentos fitoter�picos e suas formula��es. A padroniza��o dos medicamentos fitoter�picos � essencial para garantir a efic�cia terap�utica dos mesmos. Nothapodytes foetida (Wight) Sleumer (fam�lia Icacinaceae) � uma planta medicinal amea�ada de extin��o que cont�m o alcal�ide pirroloquinolina camptotecina (CPT). O alvo celular da CPT � a topoisomerase I do ADN, uma enzima envolvida na replica��o do ADN. A camptotecina tem se mostrado eficaz na remiss�o completa do cancro de pulm�o, mama, �tero e colo do �tero. No entanto, ainda n�o existem padr�es cient�ficos ou par�metros farmacogn�sticos e fitoqu�micos dispon�veis para determinar a identidade e a qualidade da N. foetida.

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