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Patch transdermico di un farmaco antipertensivo by Kumar Yadav, Pavan

Patch transdermico di un farmaco antipertensivo

by Pavan Kumar Yadav , Deepak Kumar , Preeti Pal
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Book cover type: Paperback
  • ISBN13: 9786207915248
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 84
  • Original Price: GBP 42.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 137 grams
  • BISAC Subject(s): Pharmacology

Lo scenario della ricerca è stato quello di sviluppare un sistema di rilascio transdermico di farmaci a matrice polimerica a diffusione controllata, contenente il farmaco Telmisartan con un diverso rapporto tra sistema polimerico idrofilo (HPMC) e lipofilo (EC, Eudragit RS 100), mediante la tecnica di colata con solvente su un foglio di alluminio, utilizzando il 30% w/v di Dibutyl Phthalate del peso polimerico, incorporato come plastificante e il 20% w/v, il 30% w/v di Dimethyl Sulfoxide (peso polimerico) è stato utilizzato come potenziatore della permeazione per il rilascio transdermico del farmaco. In totale sono state sviluppate nove formulazioni, utilizzando lo stesso farmaco e diversi rapporti polimerici. Tutti i cerotti transdermici sono stati valutati dal punto di vista fisico-chimico con spessore, variazione di peso, % di assorbimento di umidità, % di perdita di umidità, resistenza alla piegatura, planarità, contenuto di farmaco e % di rilascio di farmaco. . Lo studio di permeazione invitro è stato eseguito con celle di diffusione. Il rilascio massimo di farmaco in invitro è stato osservato fino a 48 ore con la formulazione F8 contenente HPMC: EC: Eudragit RS 100 in rapporto (5:0:1).

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