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Patch transdermique d'un médicament antihypertenseur by Pavan Kumar Yadav

Patch transdermique d'un médicament antihypertenseur

by Pavan Kumar Yadav , Deepak Kumar , Preeti Pal
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Book cover type: Paperback
  • ISBN13: 9786207915231
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Editions Notre Savoir
  • Publisher Imprint: Editions Notre Savoir
  • Publication Date:
  • Pages: 88
  • Original Price: GBP 42.0
  • Language: French
  • Edition: N/A
  • Item Weight: 141 grams
  • BISAC Subject(s): Pharmacology

Le scénario de cette recherche était de développer un système de délivrance de médicaments transdermique à matrice polymère contrôlé par diffusion contenant le médicament Telmisartan avec différents ratios de systèmes polymères hydrophiles (HPMC) et lipophiles (EC, Eudragit RS 100) par la technique de coulée de solvant sur une feuille d'aluminium en utilisant 30% w/v de Dibutyl Phthalate du poids polymère, incorporé comme plastifiant et 20% w/v, 30% w/v de Dimethyl Sulfoxide (poids polymère) a été utilisé comme améliorateur de perméation pour la libération de médicaments transdermiques. Au total, neuf formulations ont été développées en utilisant le même médicament et différents ratios de polymères. Tous les patchs transdermiques ont fait l'objet d'une évaluation physicochimique portant sur l'épaisseur, la variation de poids, le % d'absorption d'humidité, le % de perte d'humidité, l'endurance au pliage, la planéité, la teneur en médicament et le % de libération du médicament. . L'étude de perméation invitro a été réalisée à l'aide de cellules de diffusion. La libération maximale du médicament a été observée jusqu'à 48 heures avec la formulation F8 contenant du HPMC, de l'EC et de l'Eudragit RS 100 dans un rapport de 5:0:1.

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