Pathology of the Developing Mouse: A Systematic Approach

Name: Pathology of the Developing Mouse: A Systematic Approach
Brand: Taylor & Francis
SKU: 9781420070088
Price: 15771.0 INR
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by Brad Bolon

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ISBN13: 9781420070088
Binding: Hardcover
Subject: N/A
Publisher: Taylor & Francis
Publisher Imprint: CRC Press
Publication Date: April 27, 2015
Pages: 446
Original Price: GBP 190.0
Language: English
Edition: N/A
Item Weight: 1089 grams
BISAC Subject(s): Research, Life Sciences / Developmental Biology, and Life Sciences / Neuroscience

About The Book

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity.

The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit:

baseline anatomic and physiologic traits of developing mice
principles of good experimental design and statistical analysis for mouse developmental pathology studies
procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques;
methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids;
options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and
well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

About The Author

Brad Bolon, DVM, MS, PhD, is a Diplomate of both the American College of Veterinary Pathologists (DACVP) and the American Board of Toxicology (DABT) as well as a Fellow of both the Academy of Toxicological Sciences (FATS) and the International Academy of Toxicologic Pathology (FIATP). He is currently an associate professor in the Department of Veterinary Biosciences, College of Veterinary Medicine and also the associate director of the Comparative Pathology and Mouse Phenotyping Shared Resource, Comprehensive Cancer Center at the Columbus campus of The Ohio State University (OSU). His main professional interests are the pathology of genetically engineered mice (especially embryos, fetuses, neonates, and placentas) and toxicologic neuropathology.

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