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Pflanzliche Impfstoffadjuvantien by Gupta, Amit

Pflanzliche Impfstoffadjuvantien

by Amit Gupta
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Book cover type: Paperback
  • ISBN13: 9786208991197
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 31.23
  • Language: German
  • Edition: N/A
  • Item Weight: 109 grams
  • BISAC Subject(s): Pharmacology

Pflanzliche Adjuvanzien sind relativ einzigartig, da sie nur wenige dieser Einschr�nkungen aufweisen und den Vorteil haben, dass sie sowohl die zellul�re als auch die humorale Immunit�t stark induzieren, wodurch sie f�r ein breites Spektrum prophylaktischer und therapeutischer Impfstoffe geeignet sind. Durch den Einsatz von Adjuvanzien lassen sich oft hohe Antik�rpertiter und eine relativ gleichm� ige Reaktion erzielen.Allerdings wird Aluminiumhydroxid seit langem als Adjuvans f�r Impfstoffe verwendet, wobei es jedoch M�ngel hinsichtlich der Wirksamkeit und Wirkungsdauer aufweist oder inakzeptable lokale Reaktionen hervorruft. Seine Verwendung als Impfstoffadjuvans bietet jedoch Einschr�nkungen bei der Unterst�tzung der zellvermittelten Reaktion. Obwohl in den letzten Jahrzehnten mehrere verschiedene Adjuvanzien vorgeschlagen wurden, wurde die �berwiegende Mehrheit nicht f�r die Anwendung am Menschen zugelassen, unter anderem aufgrund mangelnder Wirksamkeit, inakzeptabler lokaler oder systemischer Toxizit�t, Schwierigkeiten bei der Herstellung, schlechter Stabilit�t und unerschwinglicher Kosten.In diesem Buch werden pflanzliche Kandidaten aus Heilpflanzen beschrieben, die im Vergleich zu Aluminium als bessere Impfstoffadjuvanzien in Frage kommen, um die Serokonversionsrate sowie die Zytokine und die induzierte Schutzwirkung nach der Impfung zu verbessern.

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