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Pharmacokinetics of Moxifloxacin in Goats: Effect of Bifenthrin by Gurmeet Singh

Pharmacokinetics of Moxifloxacin in Goats: Effect of Bifenthrin

by Gurmeet Singh , Mudasir Sultana , Adil Mehraj Khan
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Book cover type: Paperback
  • ISBN13: 9786206774006
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Scholars' Press
  • Publisher Imprint: Scholars' Press
  • Publication Date:
  • Pages: 88
  • Original Price: GBP 43.0
  • Language: English
  • Edition: N/A
  • Item Weight: 141 grams
  • BISAC Subject(s): Pharmacology

Pharmacokinetics of moxifloxacin @ 5mg.kg-1.b.wt was studied in healthy and bifenthrin intoxicated goats (n=4), following its IV administration. The MIC of moxifloxacin in plasma was maintained up to 8h in healthy goats whereas it was maintained only up to 6h in bifenthrin-intoxicated goats. The AUC was significantly decreased from 7.86 0.06g.ml-1h to 6.90 0.076g.ml-1h in bifenthrin-intoxicated goats. The distribution half-life (t1/2) and volume of distribution at steady state Vd(ss) ¬observed were 0.08 0.0008 h and 2.43 0.01L.kg-1 respectively in healthy goats and 0.081 0.0006h and 2.32 0.03L.kg-1 in bifenthrin intoxicated goats. Total body clearance was increased from 636.06 4.68 ml.kg-1h-1 in healthy to 725.4 7.92 ml.kg-1h-1 in intoxicated goats. However, decrease in elimination half life (t1/2) from 2.81 0.04h to 2.61 0.01h was observed in intoxicated goats. The dosage regimen of moxifloxacin calculated in healthy animals is 4.99 mg.kg-1 followed by 4.73 mg.kg-1 at 12h interval effective against bacterial isolates with MIC

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