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Poprawa rozpuszczalności przy użyciu poloksameru 188 i Gelucire 50/13 by Ch Niranjan Patra, Suryakanta Swain, Tapan Kumar Panda

Poprawa rozpuszczalności przy użyciu poloksameru 188 i Gelucire 50/13

by Ch Niranjan Patra , Suryakanta Swain , Tapan Kumar Panda
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Book cover type: Paperback
  • ISBN13: 9786200746528
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Wydawnictwo Nasza Wiedza
  • Publisher Imprint: Wydawnictwo Nasza Wiedza
  • Publication Date:
  • Pages: 72
  • Original Price: GBP 31.23
  • Language: Polish
  • Edition: N/A
  • Item Weight: 109 grams
  • BISAC Subject(s): Pharmacology

Celem niniejszych badań jest poprawa rozpuszczalności i szybkości rozpuszczania bosentanu. Stale dyspersje bosentanu przygotowano metodą fuzji przy użyciu dw�ch wybranych hydrofilowych nośnik�w topnych w stosunku do gelucire 50/13 i poloksameru 188. Jako adsorbent zastosowano Sylysia 350. Badania rozpuszczalności wykazaly 8- i 10-krotny wzrost rozpuszczalności dla dyspersji stalych na bazie gelucire 50/13 i poloksameru 188. Wartości energii swobodnej Gibbsa ΔGtr byly ujemne dla gelucire 50/13 i poloksameru 188, co wskazuje na spontaniczny charakter solubilizacji. Dyspersje stale wykazujące najwyższą rozpuszczalnośc zostaly sprasowane w tabletki o natychmiastowym uwalnianiu przy użyciu glikolan sodu skrobiowego jako superdesintegrującego. Badania rozpuszczalności in vitro wykazaly ponad 90% rozpuszczalności leku w ciągu 1 godziny. Gelucire 50/13 i poloksamer 188 odgrywają znaczącą rolę w zwiększaniu rozpuszczalności i rozpuszczalności leku.Adsorbent sylysia 350 może byc stosowany w celu nadania dyspersjom stalym dobrej plynności i ściśliwości. Spośr�d dw�ch nośnik�w poloksamer 188 wykazal lepszą rozpuszczalnośc i potencjal zwiększania rozpuszczalności.

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