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Progranulin and Central Nervous System Disorders by Hideaki Hara

Progranulin and Central Nervous System Disorders

by Hideaki Hara
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₹7,345.00
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Book cover type: Paperback
  • ISBN13: 9789811361883
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 183
  • Original Price: EUR 99.99
  • Language: English
  • Edition: 2019
  • Item Weight: 298 grams
  • BISAC Subject(s): Genetics, Life Sciences / Molecular Biology, and Life Sciences / Biochemistry

This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.


Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan

Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan

Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan

Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan


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