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Progress in Toxicology: Special Topics Volume 2

by Gerhard Zbinden
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Current price ₹5,967.00
Original price ₹6,109.00
Original price ₹6,109.00
Original price ₹6,109.00
(-2%)
₹5,967.00
Current price ₹5,967.00

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Book cover type: Paperback
  • ISBN13: 9783642662935
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 120
  • Original Price: GBP 46.99
  • Language: German
  • Edition: Softcover Repri
  • Item Weight: 236 grams
  • BISAC Subject(s): Chemistry / General

THE STATE OF THE ART The recent seventies have not been good times for toxicologists. Public confidence in us is shaken, mostly as a consequence of an unhappy sequence of spectacular failures: we have been surprised by a tragic transplacental carcinogenic effect of diethylstilbestrol, an old and widely prescribed synthetic estrogen. We are confronted with a small epidemic of an unusual liver tumor, angiosarcoma, induced by a simple chemical, vinylchloride, whose insiduous toxic potential we failed to "recognize for years. Our clinical colleagues had to tell us about the ulcerogenic effect of as simple a substance as potassium chloride. We also just learned of an unusual toxic reaction, pseudolupus, developing in people taking a popular fixed-combination drug, venocuran Admit- tedly, we could not have predicted this syndrome, even if we had con- sidered the possibility. We are still unable (to continue this self-flagellation) to explain the relationship between the appetite suppressant arninorex and the sud- denly increased occurrence of a lung disease posing as primary pulmonary hypertension. And worse yet, we have no way to evaluate a new deriva- tive of this class, and to predict whether or not it, too, will produce the deadly condition. We still, to my knowledge, have no plausible ex- planation why and how thalidomide caused phocomelia. Of course, we do diligently a set of teratological experiments with each new drug; we follow a protocol which has the blessing of all governmental regulatory agencies.

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