Proteasom: Tumormarker in einer marokkanischen Population

Name: Proteasom: Tumormarker in einer marokkanischen Population
Brand: Verlag Unser Wissen
SKU: 9786209844331
Price: 6922.0 INR
Availability: InStock

by Hassan Filali

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ISBN13: 9786209844331
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: March 25, 2026
Pages: 116
Original Price: USD 77.0
Language: German
Edition: N/A
Item Weight: 164 grams
BISAC Subject(s): General

About The Book

Hintergrund: Der regulierte Abbau intrazellul�rer Proteine spielt eine wesentliche Rolle bei den meisten biologischen Prozessen, insbesondere bei der Steuerung der Zellproliferation und -differenzierung. Bei Eukaryoten wird die intrazellul�re Proteolyse gr� tenteils durch das Ubiquitin-Proteasom-System gew�hrleistet. Zahlreiche Funktionsst�rungen dieses Abbaumechanismus wurden mit menschlichen Erkrankungen in Verbindung gebracht, insbesondere mit Blutneoplasien. Ziele: Das Ziel unserer Studie ist es, einen m�glichen Zusammenhang zwischen dem Auftreten bestimmter Blutkrebsarten und dem Alterungsprozess anhand der Entwicklung des Proteasoms nachzuweisen. Methodik: Die quantitative und funktionelle Analyse des Proteasoms wurde auf subzellul�rer und serologischer Ebene im Rahmen eines physiologischen (Alterung) und eines pathologischen (maligne H�mopathie) Ph�nomens mittels Sandwich-ELISA-Technik sowie durch die Verfolgung der nach enzymatischer Verdauung von f�r die Chymotrypsin-�hnliche Aktivit�t spezifischen fluoreszierenden Peptiden emittierten Fluoreszenz durchgef�hrt. Mithilfe der CMF-Technik konnte der Prozess der transmembran�ren Migration der Prosom-Untereinheiten nachgewiesen werden.

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