Pseudocholinesterasen: Pharmakogenetik - Biochemie - Klinik

Name: Pseudocholinesterasen: Pharmakogenetik - Biochemie - Klinik
Brand: Springer
SKU: 9783642879746
Price: 3089.0 INR
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by Heinz Werner Goedde , Alfred Doenicke , Klaus Altland

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ISBN13: 9783642879746
Binding: Paperback
Subject: N/A
Publisher: Springer
Publisher Imprint: Springer
Publication Date: March 29, 2012
Pages: 272
Original Price: EUR 42.05
Language: German
Edition: Softcover Repri
Item Weight: 409 grams
BISAC Subject(s): Life Sciences / Biology

About The Book

Die Pseudocholinesterase ist ein auBergewohnliches Enzym, das auf sehr verschiedenartigen Gebieten eine besondere Rolle spielt. Die Aktivitat des Enzyms im Serum wird zur Uberpriifung der Leberfunktion gemessen. Ebenso kann man durch derartige Bestimmungen auf den Grad von Ver giftungen durch Anticholinesterasen schlieBen. Es war das erste Serum Fur Anaesthe enzym, uber dessen genetische Kontrolle berichtet wurde. sisten und Chirurgen hat dieses Enzym besondere Bedeutung, da es Suc cinyldicholin abbaut und dadurch die Moglichkeit gegeben ist, ein aus gezeichnetes Kurzzeit-Muske1relaxans anzuwenden. Auf dem Gebiet der Psychiatrie dient es dazu, die Nebenwirkungen der Elektroschock-Therapie auszuschalten. Die physiologische Funktion steht immer noch zur Diskus sion. Es ist von groBem Interesse, daB die Pseudocholinesterase - im Gehirn, im Darm und in den Nervenendplatten der Muske1n - neben der "echten" Acetylcholinesterase auf tritt, die fur Acetylcholin in hohem MaBe spezifisch ist. Hohe Substratkonzentrationen hemmen dieses Enzym, wo hingegen die Pseudocholinesterase noch bei unphysiologisch hohen Kon zentrationen Acetylcholin umsetzt. Vielleicht ist die Funktion der Pseudo cholinesterase darin zu sehen, daB sie die lebensnotwendige Acetylcholin esterase bei einer unvorhergesehenen Anhaufung von Acetylcholin schutzt. Moglich ist auch, daB sie einen Schutzeffekt fUr die Acetylcholinesterase gegen kompetitive Inhibitoren, wie Z. B. das Succinyldicholin, ausubt."

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