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Recherche de Lois de Mélange Sur Des Propriétés Mécaniques by Busignies-Goddin-V

Recherche de Lois de Mélange Sur Des Propriétés Mécaniques

by Busignies-Goddin-V
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Book cover type: Paperback
  • ISBN13: 9786131509032
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 372
  • Original Price: GBP 83.0
  • Language: French
  • Edition: N/A
  • Item Weight: 545 grams
  • BISAC Subject(s): Physics / General

Le comprimé reste la forme pharmaceutique la plus présente sur le marché. Pour répondre à des contraintes technologiques et thérapeutiques, ces comprimés sont obtenus par la compression de mélanges complexes d'une substance active et d'excipients. L'objectif de cette étude a été d'évaluer les propriétés en compression et après compression de différents mélanges binaires d'excipients pharmaceutiques. Une première partie a été consacrée à l'étude de la compressibilité (cycles de compression, paramètres énergétiques, modèle de Heckel) et de la comprimabilité des excipients seuls (propriétés mécaniques). Des essais de caractérisation de la fraction solide par microtomographie X ont complété cette approche. La deuxième partie concerne l'étude des mélanges binaires avec le suivi de la variation du comportement en compression et des propriétés mécaniques en fonction de la composition des mélanges. Des essais de microtomographie X ont également été réalisés sur un des mélanges. Ce travail sur les systèmes binaires a été complété par la proposition d'un modèle pour décrire l'évolution du module d'élasticité et de la résistance à la rupture en fonction de la composition du mélange.

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