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Résistance Des Souches Grippales A(h1n1) À L Oseltamivir by Burrel-S

Résistance Des Souches Grippales A(h1n1) À L Oseltamivir

by Burrel-S
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Book cover type: Paperback
  • ISBN13: 9783841784018
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 100
  • Original Price: GBP 32.0
  • Language: French
  • Edition: N/A
  • Item Weight: 159 grams
  • BISAC Subject(s): Life Sciences / Microbiology

La vaccination est le moyen le plus efficace de lutte contre les infections grippales mais les adamantanes et les inhibiteurs de neuraminidase (INAs) ont également prouvé leur efficacité. Jusqu'à présent, une faible résistance aux INAs était observée mais de récentes études révèlent une forte prévalence de virus A(H1N1) résistants à l'oseltamivir en Europe. En position 274 du gène de la neuraminidase N1, une tyrosine remplace une histidine (H274Y) et confère un haut niveau de résistance à l'oseltamivir. De janvier à avril 2008, 21 souches isolées de patients vus en consultation de ville et hospitalisés ont été analysées par séquençage. Une RT-PCR en temps réel (technologie FRET) a été développée pour détecter rapidement la mutation H274Y. Celle-ci a été mise en évidence dans la séquence du gène N1 de 10 isolats (48%). Les résultats de RT-PCR en temps réel et de séquençage concordent parfaitement avec les données des tests phénotypiques réalisés dans un laboratoire de référence et correspondent aux données de l'OMS. Ce travail permet un suivi de la résistance aux INAs pour une meilleure prise en charge médicale des épidémies grippales saisonnières et des pandémies.

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