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Rhabdovirus aquatiques génétique inverse by Biacchesi-S

Rhabdovirus aquatiques génétique inverse

by Biacchesi-S
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Book cover type: Paperback
  • ISBN13: 9786131596681
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 200
  • Original Price: GBP 51.0
  • Language: French
  • Edition: N/A
  • Item Weight: 300 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Le virus de la nécrose hématopoïétique infectieuse (IHNV) est un pathogène viral majeur responsable de pertes économiques importantes pour les élevages piscicoles (truite et saumon). Ce virus est un virus enveloppé à ARN négatif simple brin appartenant à la famille des Rhabdoviridés. Seul un vecteur autoréplicatif spécifique des salmonidés, totalement apathogène et administrable par balnéation pourrait constituer une solution vaccinale contre ce pathogène. Aussi, un système de génétique inverse a été élaboré pour l'IHNV afin de permettre la manipulation du génome de ce virus pour l'obtention de souches vaccinales. Ce système puissant a ensuite permis d'étudier la possibilité d'échanger la glycoprotéine G de l'IHNV par celles d'autres Rhabdovirus. Enfin, l'IHNV a été utilisé comme vecteur de gènes. Ces travaux démontrent ainsi le potentiel de ce virus comme vecteur de gènes pour la vaccination des poissons.

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