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Sélection Naturelle Et Défenses Anti-Infectieuses by Giovannoni-L

Sélection Naturelle Et Défenses Anti-Infectieuses

by Giovannoni-L
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Book cover type: Paperback
  • ISBN13: 9786131535420
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 212
  • Original Price: GBP 58.0
  • Language: French
  • Edition: N/A
  • Item Weight: 318 grams
  • BISAC Subject(s): Life Sciences / Genetics & Genomics

La sélection naturelle, qu'elle soit directionnelle, balancée ou diversifiante, affecte des régions plus ou moins importantes du génome humain. Elle est la conséquence de pressions environnementales variées. Parmi celles ci, la pression infectieuse a modelé la variabilité génétique de l'homme moderne depuis sa migration à partir de foyers africains. Durant des millénaires des pathologies telles que la malaria, le typhus ou encore la tuberculose ont eut un impact sur la structure génétique des populations de la zone euro méditerranéenne. Nous avons recherché l'influence de la sélection, dans 13 populations de Méditerranée occidentale et d'Europe du Nord. L'analyse a porté sur 16 microsatellites répartis dans 11 gènes codant pour des protéines du métabolisme oxydatif, des érythrocytes et du système HLA. Un effet sélectif a ainsi été détecté sur 8 polymorphismes. Les différents tests pratiqués montrent que ces sélections sont plus le fait d'adaptations locales, sans corrélation avec la géographie. La sélection dispose donc de plusieurs solutions pour résoudre le mème problème. Le choix d'une solution avantageuse ne dépendrait que du seul hasard.

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