Selen, geny kodujące selenoproteiny i nowotwory zależne od CHEK2
Imported Edition - Ships in 18-21 Days
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Imported Edition - Ships in 18-21 Days
Free Shipping in India on orders above Rs. 500
W naszym badaniu sprawdziliśmy, czy stężenie selenu może byc przydatnym markerem do wczesnego wykrywania nowotwor�w u os�b z mutacjami CHEK2 i u losowo wybranych pacjent�w. Stwierdziliśmy bardzo istotny związek między wyższym stężeniem selenu a mniejszym prawdopodobieństwem wykrycia nowotworu w badanych grupach. Obserwacja ta jest szczeg�lnie cenna dla os�b z mutacją CHEK2, kt�re są narażone na zwiększone ryzyko zachorowania na nowotw�r. Znaleźliśmy r�wnież pewne dowody na związek między rs1139793 w TXNDR2 i rs5845 w SEP15 a ryzykiem zachorowania na nowotw�r u nosicieli CHEK2, co może byc przydatne do określenia indywidualnej oceny ryzyka. Podsumowując, stężenie selenu w surowicy wydaje się byc cennym markerem do selekcji os�b do badań kontrolnych, takich jak tomografia komputerowa lub kolonoskopia, w celu wykrycia najwcześniejszych stadi�w raka oskrzeli i raka jelita grubego. Należy r�wnież wziąc to pod uwagę w programie badań kontrolnych os�b, u kt�rych wykryto mutację CHEK2. Konieczne są dalsze analizy w celu wyjaśnienia roli zmienności gen�w selenoprotein w ryzyku zachorowania na raka u nosicieli CHEK2.
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