Sélénium, gènes codant pour les sélénoprotéines et cancers dépendants de CHEK2
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Dans notre �tude, nous avons cherch� � d�terminer si la concentration en s�l�nium pouvait �tre utilis�e comme marqueur utile pour la d�tection pr�coce des cancers chez un groupe d'individus pr�sentant des mutations CHEK2 et chez des patients non s�lectionn�s. Nous avons constat� une association tr�s significative entre une concentration �lev�e en s�l�nium et une probabilit� plus faible de d�tection du cancer dans les groupes test�s. Cette observation est particuli�rement utile pour les personnes porteuses de la mutation CHEK2, qui pr�sentent un risque accru de cancer. Nous avons �galement trouv� des preuves d'une association entre rs1139793 dans TXNDR2 et rs5845 dans SEP15 et le risque de cancer chez les porteurs de CHEK2, ce qui pourrait �tre utile pour d�terminer l'�valuation du risque personnel. En r�sum�, la concentration s�rique en s�l�nium semble �tre un marqueur utile pour la s�lection des personnes devant subir des examens de surveillance tels que la tomodensitom�trie ou la coloscopie afin de d�tecter les stades les plus pr�coces des cancers bronchiques et colorectaux. Elle devrait �galement �tre prise en compte dans le programme de surveillance des personnes chez lesquelles une mutation CHEK2 a �t� d�tect�e. Des analyses suppl�mentaires sont n�cessaires pour �lucider le r�le des variations des g�nes s�l�noprot�iques sur le risque de cancer chez les porteurs de CHEK2.
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