Sickle Cell Disease

Name: Sickle Cell Disease
Brand: Oxford University Press
SKU: 9780192630360
Price: 12936.0 INR
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by Graham R. Serjeant , Beryl E. Serjeant

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ISBN13: 9780192630360
Binding: Hardcover
Subject: N/A
Publisher: Oxford University Press
Publisher Imprint: Oxford University Press
Publication Date: June 24, 2001
Pages: 792
Original Price: USD 120.0
Language: English
Edition: Third
Item Weight: 1276 grams
BISAC Subject(s): Hematology

About The Book

Sickle cell disease is one of the grand diseases in the terminology of Victorian pathology, because its widespread and multitudinous manifestations may affect any organ system in the body. It has served as a model of molecular disease being one of the first genetic disorders to be explained at the molecular level. Since publication of the second edition, however, further advances have been made. Much has been learnt about the causes of variability in the natural history of the disease and of the reasons why there are such marked variations in the patterns of morbidity and mortality. As director of The Jamaican Sickle Cell Unit, Graham Serjeant and his colleagues have shown the disease to be extremely variable ranging from a severe clinical course with death in early childhood to mildly affected patients living to the age of 80 years. This extreme variability within a single genotype implies that other factors, both genetic and environmental, must influence expression of the disease. This new edition contains many references and incorporates ideas on the biology of the disease and the best practice in its management.

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