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Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique by Chaudhary Haresh, Patel B. N., Patel D. M.

Simvastatin Solid Dispersion Prepared by Microwave Fusion Technique

by Chaudhary Haresh , Patel B. N. , Patel D. M.
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Book cover type: Paperback
  • ISBN13: 9783846504055
  • Binding: Paperback
  • Subject: N/A
  • Publisher: LAP Lambert Academic Publishing
  • Publisher Imprint: LAP Lambert Academic Publishing
  • Publication Date:
  • Pages: 124
  • Original Price: GBP 45.57
  • Language: English
  • Edition: N/A
  • Item Weight: 191 grams
  • BISAC Subject(s): Pharmacology

Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-Simvastatin, a crystalline substance, is a widely used drug for the treatment of hypercholesterolemia. It is a BCS class II drug, having low aqueous solubility (0.76 mg/L) exhibiting poor dissolution pattern and low oral bioavailability (5%). The purpose of this study was to apply the attractive technique of the microwaves fusion for the preparation of solvent-free solid dispersions and to enhance the solubility and dissolution rate of simvastatin by a solid dispersion.

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