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Stato fisiopatologico orchestrato dal Coronavirus by Udema, Ikechukwu

Stato fisiopatologico orchestrato dal Coronavirus

by Ikechukwu Udema
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Book cover type: Paperback
  • ISBN13: 9786208770129
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 152
  • Original Price: GBP 59.94
  • Language: Italian
  • Edition: N/A
  • Item Weight: 214 grams
  • BISAC Subject(s): Life Sciences / Biochemistry

La viscosit� della membrana influisce sul tempo necessario a un virus per entrare e uscire dalle cellule e la quantit� di proteine e colesterolo nella membrana pu� impedire al virus di interagire con la zattera lipidica. La costante di dissociazione di equilibrio pu� essere abbassata da farmaci che riducono il colesterolo o si legano in modo reversibile, rendendo il legame meno possibile dal punto di vista termodinamico. Rimuovendo il colesterolo dalla membrana, inibitori come le HDL possono ridurre le quantit� di ACE2 e furina proteasi nelle zattere lipidiche. I viscogeni possono impedire ai precursori del colesterolo o ai composti intermedi di interagire con gli enzimi. Prolungando il periodo in cui le particelle virali si legano all'ACE-2, si legano e producono sintomi, � possibile diminuire il tasso di infezione o di virulenza. La generazione di colesterolo � soggetta a una caratterizzazione termodinamica che pu� dimostrare come la replicazione dell'RNA virale possa essere controllata. Infine, una costante di equilibrio adimensionale � la pi� appropriata per calcolare quantit� termodinamiche come l'energia libera, l'entalpia e l'entropia di legame. Un valore pi� grande della costante di equilibrio senza unit� che diminuisce nel tempo richiede un intervento medico precoce.

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