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Système de Sécrétion de Type II by Robert-V

Système de Sécrétion de Type II

by Robert-V
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Book cover type: Paperback
  • ISBN13: 9786131555442
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Omniscriptum
  • Publisher Imprint: Omniscriptum
  • Publication Date:
  • Pages: 232
  • Original Price: GBP 59.0
  • Language: French
  • Edition: N/A
  • Item Weight: 345 grams
  • BISAC Subject(s): Life Sciences / Microbiology

Pseudomonas aeruginosa sécréte divers facteurs de virulence par la machinerie de sécrétion de type II. La sécrétion s'effectue en deux temps: l'exoprotéine franchit la membrane interne (MI) via la machinerie Sec puis la membrane externe (ME) par l'appareil de sécrétion Xcp. Le système Xcp est constitué de 12 protéines (XcpA, XcpP-Z), localisées dans la MI, à l'exception de XcpQ, protéine de ME. L'étude de la formation de sous-complexes au sein du sécréton ainsi que la recherche de domaines d'interaction entre protéines a révélé les multiples fonctions de trois protéines du système: les protéines XcpP, XcpY et XcpZ. Le complexe XcpYZ permettrait dans un premier temps l'ancrage des composants de la machinerie à un endroit précis dans la MI pour l'assemblage de l'appareil de sécrétion. Le complexe XcpYZP interviendrait ensuite dans le transfert d'énergie de la MI à la ME afin d'induire l'ouverture du pore de ME XcpQ pour libérer les exoprotéines dans le milieu extracellulaire. Cette étude a permis pour la première fois de mettre en évidence les interactions dynamiques et transitoires qui résident au sein de la machinerie de sécrétion de type II.

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