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Test cutaneo alla tubercolina by Mariem Nouira

Test cutaneo alla tubercolina

by Mariem Nouira , Hazem Ben Rayana , Samir Ennigrou
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Book cover type: Paperback
  • ISBN13: 9786208329679
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Edizioni Sapienza
  • Publisher Imprint: Edizioni Sapienza
  • Publication Date:
  • Pages: 68
  • Original Price: GBP 51.0
  • Language: Italian
  • Edition: N/A
  • Item Weight: 114 grams
  • BISAC Subject(s): General

Introduzione: Le forme gangliari di tubercolosi spesso sfuggono alla diagnosi con i test convenzionali. Il nostro obiettivo è stato quello di valutare le prestazioni del test cutaneo alla tubercolina nella diagnosi di tubercolosi attiva in Tunisia, utilizzando la metodologia della curva ROC. Metodologia: si tratta di uno studio multicentrico caso-controllo condotto in 11 cliniche per la tubercolosi (DAT) in Tunisia nel 2014. Risultati: in totale, abbiamo incluso 1053 pazienti suddivisi in 339 casi e 714 controlli. Il diametro medio dell'indurimento del TST alla tubercolina è risultato significativamente più alto nei casi rispetto ai controlli (13,7 mm contro 6,2 mm; p=10-6). L'area sotto la curva (AUC) è risultata pari a 0,789[95% CI:0,758-0,819;p=0,01], il che corrisponde a un moderato potere discriminante per questo test. Il valore di cut-off per il diametro dell'indurimento della reazione intradermica alla tubercolina è risultato il più discriminante, associato al miglior rapporto di sensibilità (73,7%) e specificità (76,6%): 11 mm con un indice di Youden di 0,503.Conclusioni: possiamo concludere che il test cutaneo alla tubercolina può essere utilizzato per diagnosticare la tubercolosi con buona sensibilità e specificità. Tuttavia, la sua interpretazione e lettura rimangono difficili e molto soggettive.

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