The Interface Between Innate and Acquired Immunity

Name: The Interface Between Innate and Acquired Immunity
Brand: Springer
SKU: 9783540428947
Price: 11017.0 INR
Availability: InStock

by M. D. Cooper , H. Koprowski

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ISBN13: 9783540428947
Binding: Hardcover
Subject: N/A
Publisher: Springer
Publisher Imprint: Springer
Publication Date: January 1, 2002
Pages: 131
Original Price: EUR 149.99
Language: English
Edition: N/A
Item Weight: 216 grams
BISAC Subject(s): Immunology

About The Book

All multicellular organisms may possess innate immunity mediated by defense mechanisms with which the organism is born. In recent years much has been learned about the diversity of innate immune mechanisms. A large array of naturally produced antimicrobial peptides has been de- fined. A variety of cell surface receptors that recognize common patterns displayed by infectious organisms have been identified along with the intracellular pathways that these receptors use to activate cellular defense functions. Cell surface receptors on natural killer (NK) cells have been shown to sense microbial invasion in neighboring cells, thereby setting into motion their elimination by cy- totoxic mechanisms. Other receptors have been found to facilitate phagocytosis and intracellular killing of microbes by phagocytic cells. These and other natural defense mechanisms have traditionally been viewed as the first line of body defense in vertebrate species that also possess the capacity for acquired or adaptive immunity. Sharks and all of the other jawed vertebrates generate large repertoires of T and B lymphocyte clones that display different antigen- specific receptors in the form ofT cell receptors (TCR) and immunoglobulins (Ig) that allow them to recognize and respond to antigens in collaboration with antigen-present- ing cells. Memory T and B cells are then generated to allow faster and heightened cellular and humoral immune re- sponses on secondary antigen encounter. In recent years it has also become obvious that innate immune responses can directly influence adaptive immune responses in ways that will enhance body defense.

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