The P53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology

Name: The P53 Family: A Subject Collection from Cold Spring Harbor Perspectives in Biology
Brand: Cold Spring Harbor Laboratory Press,U.S.
SKU: 9780879698300
Price: 9426.0 INR
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by Arnold J. (EDT)/ Lane, David P. Levine

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ISBN13: 9780879698300
Binding: Hardcover
Subject: N/A
Publisher: Cold Spring Harbor Laboratory Press,U.S.
Publisher Imprint: Cold Spring Harbor Laboratory Press,U.S.
Publication Date: June 22, 2010
Pages: 368
Original Price: GBP 84.0
Language: English
Edition: N/A
Item Weight: 966 grams
BISAC Subject(s): Life Sciences / Genetics & Genomics

About The Book

The p53 tumor suppressor gene--the "guardian of the genome"--protects cells against genotoxic stress but is mutated in many cancers. It encodes one of a family of transcription factors (p53, p63, and p73) that regulate cell proliferation, differentiation, senescence, and cell death. Mutations in p53 allow cells to escape normal growth controls and thereby contribute to tumor malignancy.
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology provides a comprehensive review of the functions of the p53 family. The contributors examine the normal roles of these transcription factors, the regulatory mechanisms that control p53 activity, and the part played by p53 mutations in tumorigenesis. They also discuss the evolution of the p53 family, which may originally have arisen to protect the integrity of the germ line. This collection also covers the structure of p53 and its isoforms, model systems for analyzing p53 function, studies of p53 polymorphisms, and therapeutic approaches aimed at targeting p53 defects in cancer.

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