The Principles and Practices of Infectious Diseases
Foundational Science, Research-Driven Practice, and Global Perspectives in Disease Management
This is a clinician-focused, research-grounded guide to the full continuum of infectious diseases-from molecular pathogenesis and host immune dynamics to bedside decision-making, outbreak control, and health-system leadership. Written for practicing physicians, trainees, pharmacists, microbiologists, infection preventionists, and global health professionals, the book translates cutting-edge science into clear, defensible choices at the point of care.
Across its volumes, you'll find an integrated, "bench-to-bedside-to-population" approach that pairs mechanistic insight with pragmatic algorithms and checklists. Chapters open with crisp learning objectives and close with key takeaways, pearls and pitfalls, and pragmatic stewardship considerations to support safe, cost-conscious care.
What's inside: Foundational Science that matters in clinic: microbial genetics and pathogenesis, host immunity, microbiome interactions, virulence and transmission, pharmacology and PK/PD principles that drive antimicrobial selection and dosing.
State-of-the-art Diagnostics: optimal use of cultures, molecular assays and syndromic panels, point-of-care testing, imaging for deep infections, interpretation of biomarkers, and diagnostic stewardship to reduce overuse and delay.
Therapeutics & Stewardship: empiric and targeted therapy frameworks, IV-to-PO conversion, dosing in renal/hepatic dysfunction and obesity, therapeutic drug monitoring, antifungal/antiviral/antiparasitic strategies, and de-escalation/stop rules.
Clinical Syndromes by presentation and pathogen: sepsis, CNS infections, pneumonia (CAP, HAP/VAP), endocarditis, UTI/pyelonephritis, SSTIs, osteoarticular infections, intra-abdominal infections, CLABSI/CAUTI/SSI bundles, and device-related infections.
Special Populations: pregnancy, neonates and pediatrics, geriatrics, oncology and transplant recipients, ICU patients, and people with advanced immunosuppression.
Infection Prevention & Hospital Epidemiology: surveillance methods, isolation precautions, environmental hygiene, outbreak investigation, and program metrics that withstand regulatory review.
Global & One Health Perspectives: travel and tropical medicine, vector-borne and zoonotic threats, climate-sensitive infections, refugee and humanitarian settings, and cross-border surveillance.
Public Health, Policy, and Leadership: risk communication, crisis standards, ethics in scarcity, antimicrobial access and equity, and implementation science for durable practice change.
Education & Research Methods: teaching ID at the bedside, building protocols, quality improvement, study design, and critical appraisal for evidence-based decisions.
How this book helps you practice better: Clear pathways, fewer errors: diagnostic and treatment algorithms, dosing boxes, and contraindication alerts make complex decisions faster and safer.
Stewardship built-in: every therapeutic section pairs efficacy with resistance ecology, adverse effect profiles, and cost-conscious alternatives.
Who should read this book: Hospitalists, internists, ID specialists, intensivists, surgeons, pediatricians, pharmacists, advanced practice providers, microbiology and public health teams, trainees preparing for boards, and leaders responsible for infection prevention and antimicrobial stewardship.
