Toleranz bei der allogenen Nierentransplantation von Lebendspendern

Name: Toleranz bei der allogenen Nierentransplantation von Lebendspendern
Brand: Verlag Unser Wissen
SKU: 9786209822568
Price: 7010.0 INR
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by Aruna V. Vanikar

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ISBN13: 9786209822568
Binding: Paperback
Subject: N/A
Publisher: Verlag Unser Wissen
Publisher Imprint: Verlag Unser Wissen
Publication Date: April 29, 2026
Pages: 112
Original Price: USD 78.0
Language: German
Edition: N/A
Item Weight: 159 grams
BISAC Subject(s): General

About The Book

Transplantationstoleranz kann definiert werden als normales Transplantat�berleben ohne Immunsuppression bei Aufrechterhaltung einer intakten Immunit�t. Strategien zur Toleranzinduktion (TI) umfassen die Induktion von Chimerismus und/oder klonaler Deletion. Spenderspezifische Transfusionen (DST) und Stammzellen (SCs) haben sich als TI etabliert. In dieser parallelen, offenen 2-armigen Studie unter nicht-myeloablativer Konditionierung mit DST als erstem Arm und SCs als zweitem Arm, ohne Einsatz konventioneller Immunsuppression. Die �berwachung umfasste SCr (mg/dL), DSA und MLR. Protokollbiopsien waren nach 100 Tagen und j�hrlich bei willigen Patienten geplant. Im Falle einer Absto ung/DSA/MLR war eine Rettungsimmunsuppression geplant. Die Patienten�berlebensrate betrug in den ersten 2 Jahren in beiden Armen 100 %; 5 Jahre nach der Transplantation lag sie bei 80 % mit SC und bei 90 % mit DST. Das todeszensierte Transplantat�berleben betrug im ersten Jahr in beiden Gruppen 100 % und nach 5 Jahren 80 % bei SC und 70 % bei DST. Der mittlere SCr-Wert lag bei 1,52 bei SC und bei 1,97 bei DST. F�nf Patienten aus der SC-Gruppe und drei aus der DST-Gruppe hatten eine erfolgreiche TI. Die MLR war in beiden Gruppen negativ. Eine DSA trat bei 2 Patienten der SC-Gruppe ohne Transplantatdysfunktion und bei 4 der DST-Gruppe mit Transplantatdysfunktion auf. Somit erleichtern SCs die TI bei LDRT unter nicht-myeloablativer Konditionierung.

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Toleranz bei der allogenen Nierentransplantation von Lebendspendern

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