Vom Nmr-Spektrum Zur Strukturformel Organischer Verbindungen: Ein Kurzes Praktikum Der Nmr-Spektroskopie
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Studenten aller Fachrichtungen der Chemie und Pharmazie lernen heute Strukturaufkl�rung durch kernmagnetische Resonanz (NMR). Es gibt kaum eine Diplom-, Examens- oder Doktorarbeit, in der nicht ein Problem mit Hilfe von NMR gel�st wird. Gefragt sind daher preiswerte Texte, die dem Studenten an Beispielen zeigen, wie man NMR bei der Strukturaufkl�rung einsetzt. Etab- lierte Werke der NMR-Spektroskopie behandeln physikalische Grundlagen alter und neuer Methoden sowie die Zusammenh�nge zwischen NMR-Parametern und chemischer Struktur. Sie vermitteln kaum das "gewu t wie" der Strukturauf- kl�rung mit NMR, geben also wenig konkrete taktische und strategische Hinweise auf den gedanklichen Weg "vom NMR-Spektrum zur Strukturformel". Dieser aus zahlreichen Vorlesungen und Seminaren herangereifte Text ist ein Versuch, dem Studenten, Diplomanden und Doktoranden einen systematischen, gut lesbaren und preiswerten Einstieg in die Taktik der Strukturaufkl�rung durch NMR zu vermitteln. Er stimmt den Leser mit einem absichtlich sehr kurzen Repetitorium der elementaren Grundbegriffe, Me gr� en und Me ver- fahren ein. Etablierte Lehrb�cher sollen ja nicht ersetzt werden. Es folgt eine Einf�hrung in die Taktik der Strukturaufkl�rung mit ein- und zweidi- mensionalen NMR-Methoden. Im Vordergrund steht dabei stets die Frage, wie Messungen und daraus resultierende Parameter in Teilstrukturen �bersetzt werden. Das Kapitel orientiert nicht, wie sonst �blich, �ber physikalische Grundlagen der Me methoden, Theorie der chemischen Verschiebung und Spin- Spin-Kopplung. Vielmehr gliedert es sich in die wesentlichen Teilaspekte der Molek�lstruktur, welche bei der Identifizierung jeder Verbindung zu kl�ren sind: Konstitution, relative Konfiguration und Konformation, abso- luteKonfiguration, intra- und intermolekulare Wechselwirkungen, Molek�l- dynamik.
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