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Zur Herzwirkung Von Inhalationsanaesthetica: Der Isolierte Katzenpapillarmuskel ALS Myokard-Modell by H. P. Siepmann

Zur Herzwirkung Von Inhalationsanaesthetica: Der Isolierte Katzenpapillarmuskel ALS Myokard-Modell

by H. P. Siepmann
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Book cover type: Paperback
  • ISBN13: 9783540092308
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Springer
  • Publisher Imprint: Springer
  • Publication Date:
  • Pages: 68
  • Original Price: EUR 51.39
  • Language: German
  • Edition: N/A
  • Item Weight: 137 grams
  • BISAC Subject(s): General

1. 1 Inhalationsanaesthetica und ihre Nebenwirkungen . . . . . . . . . . . . . . . . . . . . 1 1. 2 Die unterschiedlich starke Myokardwirkung von Halothan und Enfluran am isolierten Papillarmuskel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 1. 3 Die möglichen Ursachen für divergierende in-vitro-Versuchsergebnisse . . . . . . . . 2 1. 4 Die Probleme bei der Verabreichung von Inhalationsanaesthetica bei in-vitro- Versuchen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 1. 5 Fragestellungen. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 2 Untersuchungsmethode . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 1 Versuchsaufbau . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 1. 1 Organbad, Nährlösung und Stimulation. . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. 1. 2 Kraftübertragung . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 Messung der Muskelverkürzung und Verkürzungsgeschwindigkeit . . . . . . . . . . . 8 2. 1. 3 2. 1. 4 Messung der Spannungsentwicklung und der maximalen Spannungsanstie- geschwindigkeit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. 5 Registriersystem. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2. 1. 6 Me grö en . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2. 1. 7 Verabreichungsverfahren fur Inhalationsanaesthetica . . . . . . . . . . . . . . . . . . . 9 2. 1. 8 Gaschromatographische Analysen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2. 2 Versuchsablauf . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 2. 3 Die Verarbeitung des Datenmaterials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10 3 Ergebnisse . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3. 1 Vergleich der Myokard-Wirkung von Halothan und Enfluran am isolierten Papillarmuskel der Katze . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 3. 1. 1 Die Myokardwirkung in Abhängigkeit von den Dampfkonzentrationen in mg% . . 11 3. 1. 2 Notwendigkeit und Voraussetzung für die Umwandlung der Dampfkonz- trationen von Gewichts- in Volumeneinheiten (mg% in Vol. %) . . . . . . . . . . . . 13 3. 1. 3 Die Myokardwirkung in Abhängigkeit von den Dampfkonzentrationen in Vol. % 13 3. 1. 4 Vergleich der Myokardwirkung von Halothan und Enfluran bei Berücksichtigung der unterschiedlichen narkotischen Potenz beider Dämpfe . . . . . . . . . . . . . . . 15 3. 2 Einflu von Temperatur, Reizfrequenz und pH-Wert auf die Myokardwirkung von Enfluran . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3. 2. 1 Vorbemerkungen . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 3. 2. 2 Die Bedeutung der Temperatur der Perfusionslösung für die Myokardwirkung von Enfluran . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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