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Zytogenetik der malignen hämatologischen Erkrankungen by Amel Sebaa

Zytogenetik der malignen hämatologischen Erkrankungen

by Amel Sebaa
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Book cover type: Paperback
  • ISBN13: 9786208903855
  • Binding: Paperback
  • Subject: N/A
  • Publisher: Verlag Unser Wissen
  • Publisher Imprint: Verlag Unser Wissen
  • Publication Date:
  • Pages: 96
  • Original Price: GBP 52.98
  • Language: German
  • Edition: N/A
  • Item Weight: 141 grams
  • BISAC Subject(s): Life Sciences / Biology

Bei malignen h�matologischen Erkrankungen lassen sich zahlreiche Chromosomenanomalien in Bezug auf die Anzahl und vor allem die Struktur identifizieren. Sie haben die Besonderheit, dass sie erworben sind und sich klonal entwickeln. Bei soliden Tumoren wurden verschiedene Arten von Chromosomenanomalien identifiziert. Neben den zytologischen und histologischen Daten ist die Identifizierung einer genetischen Anomalie ein integraler Bestandteil des diagnostischen Prozesses bei malignen h�matologischen Erkrankungen und bestimmten soliden Tumoren. Die Identifizierung dieser Anomalien spielt auch bei der prognostischen Stratifizierung und der Wahl der Therapie eine Rolle und erm�glicht die Beurteilung der Resterkrankung nach der Behandlung. Die Chromosomenanomalien, die bei malignen h�matologischen Erkrankungen festgestellt werden, sind erworben (auf den malignen Klon beschr�nkt), klonal, prim�r oder sekund�r. Prim�re zytogenetische Anomalien sind in der Regel spezifisch f�r eine Krankheitseinheit, w�hrend sekund�re Anomalien weniger spezifisch sein k�nnen; letztere spiegeln eine Entwicklung des malignen Klons wider und weisen auf seine genetische Instabilit�t hin.

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